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Bioanalytical Scientist - Virology

Quality & Laboratory
Dublin South
Claire McGuckin
Permanent
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Job Reference: 1AG_1654766421

Summary:

Responsibilities

Laboratory Support

  • Responsible for sample preparation, running, data analysis and reporting of results of analytical analysis for multiple R&D projects in accordance with supplied client guidelines/protocols.
  • Work collaboratively with project team (scientists/engineers) to ensure both in-process and final product analytical testing is carried out in a timely manner to ensure project deadlines are achieved.
  • Carry out a technical transfer of analytical project methods and clarify any issues with senior Analysts internally and/or analytical scientists externally as required at the beginning of projects, highlight any potential issues/questions that may need to be addressed.
  • Carry out equipment ownership responsibilities for assigned equipment, troubleshoot, develop solutions for issues and escalate to senior analysts or the Functional Lead as required.
  • Demonstrate competency in the execution in some of the following bio-analytical techniques: HPLC/UPLC (eg: peptide mapping, glycan analysis, aggregates analysis (SEC) and charged variant analysis), microscopy, fluorescence microscopy, cell proliferation assays, protein quantification (Bradford / BCA etc), DNA/RNA extraction and quantification, cell-counting, flow cytometry, electrophoretic techniques such as capillary electrophoresis, imaged CIEF, SDS-PAGE, and Western blotting, restriction digest assays, cell-based bioassays, immunoassays, (ELISA), qPCR.
  • The ideal candidate will have experience in Virology and in particular the characterisation of viral vectors such as adenovirus, associated adenovirus (AAV), lentivirus, Herpes Simplex virus, Vaccinia, retrovirus etc. Expertise should include a number of the following techniques specific to virology such as: Dynamic Light Scattering, Nanoparticle Tracking Analysis (NanoSight), qPCR, infectious titer (TCID50, PFU, immunofocus assays), ELISA, full-empty capsid ratios, Western blot, Scanning Electron Microscopy or protein/DNA/RNA quantification.
  • Demonstrate proficiency in cell culture (adherent and suspension cell lines) as necessary to support cell-based bioassays.
  • Prepare technical presentations and report material, and present the issues, results and project progress across multiple clients as required.
  • Ensure the operation to GLP standard within a R&D laboratory is maintained at all times.
  • Ensure that safe working practices are adhered to in line with relevant local and legal requirements.
  • Based on needs, develop and introduce new techniques, methods and processes to improve business effectiveness.
  • Support the training and development of team members - scientists/engineers
  • Ensure all laboratory procedures are adhered to e.g. removal of expired material and reagents, disposal of waste, movement of client samples etc.
  • Liaise with the Laboratory Manager as required to maintain a shared awareness of the issues requiring attention within the laboratories.

Requirements

  • Minimum of 1-2+ years industry experience in bio-analytical science (if PhD qualified); minimum of 3-4 years industry experience (if masters qualified); minimum of 4+ years industry experience (if Bachelors degree qualified); minimum of 5+ years of experience in a biological lab where bio-analytical methods are a major focus.
  • Ability to work in a dynamic and multidisciplinary environment.
  • Ability to write and follow an experimental protocol.
  • Experience in one of: protein analysis, DNA/RNA analysis, or analytical methods related to immunology or virology.
  • Self-motivated with a "can-do" attitude.
  • Strong technical writing skills and previous technical presentation experience.
  • Ability to disseminate information to research team and directors.
  • Hands-on experience with analytical methods related to virology and/or immunology
  • Good knowledge of bio-analytical method troubleshooting / optimisation and method validation.
  • Experience of cell-culture and aseptic technique in support of cell-based bioassays.

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